Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

200
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
200
Regulation of Stroke Volume01:27

Regulation of Stroke Volume

4.6K
The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
4.6K
Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

2.8K
Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
2.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Potential role of the <i>Trpv4 c.1491+1G>A</i> mutation in pulmonary fibrosis in a gene-edited mouse model.

Frontiers in genetics·2026
Same author

3-O-p-coumaroylquinic acid and 4-O-p-coumaroylquinic acid from Hemerocallis citrina Baroni exert antidepressant effects via CA/Dopa/DA/NE and PKA/CREB/BDNF signaling pathways.

NPJ science of food·2026
Same author

High-Resolution Mapping of RNA-RNA Interactions Across the HIV-1 Genome With HicapR.

Bio-protocol·2026
Same author

Diagnostic accuracy of GeneReady MTB assay on sputum for detecting pulmonary tuberculosis: a prospective multicenter study in China.

Journal of clinical microbiology·2026
Same author

Dual-engineered small extracellular vesicles targeted delivery miR-126 for reducing age-related bone loss.

Biomedical materials (Bristol, England)·2026
Same author

Development and external validation of a machine learning model for cardiovascular risk prediction in individuals with chronic lung disease: Evidence from CHARLS and ELSA.

Digital health·2026

Related Experiment Video

Updated: Jan 11, 2026

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model
08:22

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model

Published on: June 20, 2025

418

Elevated WBC/HDL Ratio Predicts Poststroke Functional Prognosis.

Haobo Wang1, Xiangqi Kong1, Xinyue Yuan1

  • 1Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, China.

Brain and Behavior
|November 12, 2025
PubMed
Summary
This summary is machine-generated.

The white blood cell to high-density lipoprotein cholesterol (WBC/HDL) ratio predicts poor outcomes in acute ischemic stroke (AIS) patients. Higher WBC/HDL ratios indicate a greater risk of unfavorable 90-day functional outcomes after stroke.

Keywords:
WBC/HDL ratioinflammationprognosisstroke

More Related Videos

Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice
09:48

Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice

Published on: May 4, 2015

14.2K
Stereological and Flow Cytometry Characterization of Leukocyte Subpopulations in Models of Transient or Permanent Cerebral Ischemia
12:42

Stereological and Flow Cytometry Characterization of Leukocyte Subpopulations in Models of Transient or Permanent Cerebral Ischemia

Published on: December 28, 2014

16.1K

Related Experiment Videos

Last Updated: Jan 11, 2026

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model
08:22

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model

Published on: June 20, 2025

418
Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice
09:48

Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice

Published on: May 4, 2015

14.2K
Stereological and Flow Cytometry Characterization of Leukocyte Subpopulations in Models of Transient or Permanent Cerebral Ischemia
12:42

Stereological and Flow Cytometry Characterization of Leukocyte Subpopulations in Models of Transient or Permanent Cerebral Ischemia

Published on: December 28, 2014

16.1K

Area of Science:

  • Neurology
  • Biomarkers
  • Inflammation

Background:

  • Inflammation and lipid metabolism are key in acute ischemic stroke (AIS) pathogenesis and outcomes.
  • The white blood cell to high-density lipoprotein cholesterol (WBC/HDL) ratio is a novel biomarker for systemic inflammation and anti-inflammatory capacity.

Purpose of the Study:

  • To evaluate the prognostic value of the WBC/HDL ratio in predicting 90-day functional outcomes in AIS patients.

Main Methods:

  • Retrospective enrollment of 837 AIS patients.
  • Calculation of baseline WBC/HDL ratios at admission.
  • Assessment of 90-day functional outcomes using the modified Rankin Scale (>2 indicating unfavorable outcomes).
  • Logistic regression, restricted cubic spline (RCS) curves, and subgroup analysis were used to assess associations.

Main Results:

  • Higher WBC/HDL ratios were significantly associated with poor functional outcomes.
  • This association remained robust after adjusting for covariates (adjusted OR: 1.2589; p=0.0001).
  • The highest WBC/HDL tertile showed nearly double the risk of poor outcomes compared to the lowest tertile, with a linear dose-response relationship observed via RCS analysis.
  • Subgroup analyses confirmed consistent associations across different patient demographics and conditions.

Conclusions:

  • The WBC/HDL ratio independently predicts 90-day functional outcomes in AIS.
  • It serves as a practical biomarker for early risk stratification in AIS patients.