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Updated: Aug 4, 2026

Near Infrared Photoimmunotherapy for Mouse Models of Pleural Dissemination
Published on: February 9, 2021
Mitochondria-anchored aggregation-induced emission luminogens induce pyroptosis for enhanced photodynamic
Lei Hao1, Xiaoli Huo1, Yi Zhang1
1State Key Laboratory of Fine Chemicals, MOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, 2 Linggong Road, Dalian 116024, China. wangjinyun67@dlut.edu.cn.
Abstract:
In this study, we report a mitochondria-anchored, aggregation-induced emission photosensitizer named Kl-CHO. It has the ability to anchor mitochondria for an extended period. When subjected to light irradiation, the reactive oxygen species produced by Kl-CHO disrupt mitochondrial redox homeostasis. This causes mitochondrial dysfunction, which induces pyroptosis and amplifies cellular immunogenic death.
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