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Updated: Jan 11, 2026

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
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ALDOA-Mediated Metabolic Reprogramming is a Targetable Vulnerability for Ferroptosis Sensitization in Cancer.

Pengqi Wang1, Kezhang He1, Bowen Wang1

  • 1New Cornerstone Science Laboratory, School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|November 12, 2025
PubMed
Summary
This summary is machine-generated.

Aldolase A (ALDOA) reprograms cancer cell metabolism to resist ferroptosis. Suppressing ALDOA or using ALDOA inhibitors selectively sensitizes cancer cells to ferroptosis, offering a targeted cancer therapy approach.

Keywords:
ALDOAautophagycancerferroptosislipid metabolismmetabolic reprogramming

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Last Updated: Jan 11, 2026

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cancer Research

Background:

  • Ferroptosis is a promising cancer therapy strategy.
  • Non-selective ferroptosis induction limits therapeutic efficacy due to effects on normal cells.

Purpose of the Study:

  • Identify novel targets for selective ferroptosis induction in cancer.
  • Investigate the role of aldolase A (ALDOA) in ferroptosis resistance.

Main Methods:

  • Metabolomic analysis
  • Autophagy assays
  • In vitro and in vivo cancer cell models
  • ALDOA inhibition studies

Main Results:

  • Aldolase A (ALDOA) reprograms lipid metabolism to confer ferroptosis resistance in cancer cells.
  • ALDOA suppression or inhibition increases cancer cell susceptibility to ferroptosis.
  • ALDOA depletion leads to fructose 1,6-bisphosphate accumulation and enhanced autophagy-dependent degradation of lipid-modifying enzymes.
  • ALDOA inhibitors selectively induce ferroptosis in cancer cells both in vitro and in vivo.

Conclusions:

  • Aldolase A (ALDOA) is a key mediator of metabolic reprogramming that confers resistance to ferroptosis in cancer.
  • Targeting ALDOA represents a viable strategy for selective ferroptosis sensitization in cancer therapy.