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Serum Uric Acid as a Potential Risk Marker for Atherosclerotic Cardiovascular Disease in Japanese Adults: Using the
Takashi Matsuyama1, Mito Yamawaki1, Jun Furuya1
1Renal Division, Department of Internal Medicine, Iwata City Hospital, Iwata, Japan.
Introduction:
Atherosclerotic cardiovascular disease (ASCVD) risk profiles vary among populations. In Japan, a prediction model for the 10-year estimate of ASCVD risk, integrating coronary artery disease and atherothrombotic cerebral infarct risk assessments, has been developed based on the Hisayama Study. While hyperuricemia can promote atherosclerosis, serum uric acid levels are not included as a risk factor in the 10-year ASCVD prediction model.
Methods:
We investigated the association between serum uric acid levels and 10-year ASCVD risk in 5,984 Japanese adults (3,285 males, 2,699 females) aged 40-79 years who underwent health check-ups between 2020 and 2022. The 10-year ASCVD risk scores were calculated using the aforementioned prediction model.
Results:
Participants in the lowest quartile of serum uric acid levels (3.8 ± 0.6 mg/dL) had a mean 10-year ASCVD risk of 2.1 ± 3.2%, while those in the highest quartile (7.2 ± 0.7 mg/dL) had a mean risk of 4.3 ± 4.6% (p < 0.001). A significant positive correlation was observed between serum uric acid levels and 10-year ASCVD risk scores (r = 0.34, p < 0.001). Multiple linear regression analysis also revealed that serum uric acid levels remained an independent predictor of 10-year ASCVD risk after adjusting for other risk factors (β = 0.02, p < 0.001).
Conclusions:
This study indicates that serum uric acid levels may serve as a useful marker for ASCVD risk assessment, particularly in the Japanese population.
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