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Updated: Jan 11, 2026
Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
High expression of CDKN2A in oral squamous cell carcinoma is associated with distant metastasis: Cell-free DNA as a
Natsuki Eboshida1, Atsuko Hamada1, Asami Tanigawa1
1Department of Oral Oncology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan.
Abstract:
Oral squamous cell carcinoma (OSCC) shows a high incidence and is associated with a higher rate of mortality, particularly in developing countries. Although the development of treatment strategies has been remarkable, the 5-year survival rate remains low (often <50%). Surgery and chemoradiotherapy are the standard treatments; however, there are limited factors that can predict metastasis. Liquid biopsy is promising in treating various cancers, including OSCC. In previous studies on OSCC, associations were identified among circulating tumour cell clusters, cell-free DNA (cfDNA) size/quantity and prognosis. The present study aimed to explore the role of CDKN2A and TP53 in OSCC using immunohistochemistry. Next-generation sequencing analysis of both cfDNA and tissues from two patients with poor prognoses was performed, and two common mutated genes, TP53 and CDKN2A, were detected. The CDKN2A-positive group showed metastasis in 50% of cases and shorter overall survival in OSCC. Overall, CDKN2A protein expression is a potential prognostic marker for OSCC.
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