Related Experiment Video
Updated: Jan 11, 2026
Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway
Published on: August 23, 2024
Donor-derived PLA2R-positive membranous nephropathy after post-mortal kidney transplantation
Bastian Robinson Baarz1, Jan Jochims2, Nadine Unterwalder3
1Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Germany.
Abstract:
Donor-derived glomerular diseases after organ transplantation are rare and may be challenging to diagnose. We report two kidney transplant recipients from a deceased donor with previously undiagnosed phospholipase A2 receptor (PLA2R)-positive membranous nephropathy (MN). Recipient 1 experienced delayed graft function with gross albuminuria; biopsy showed PLA2R-positive MN. Recipient 2 had immediate graft function. In both patients anti-PLA2R sera were negative, while retrospective donor testing confirmed an anti-PLA2R titer, suggesting donor-derived idiopathic MN. Follow-up under standard immunosuppression showed improving creatinine and partial remission of albuminuria in Recipient 1, and stable function with modest, transient albuminuria in Recipient 2. Thus, kidneys from donors with MN can yield acceptable outcomes.
Insights
Donor-derived phospholipase A2 receptor-positive membranous nephropathy (MN) is rare. Kidneys from donors with undiagnosed MN can lead to acceptable transplant outcomes, even with initial graft dysfunction.
Area of Science:
- Nephrology
- Transplantation Immunology
- Glomerular Diseases
Background:
- Donor-derived glomerular diseases are uncommon and difficult to diagnose post-transplant.
- Phospholipase A2 receptor (PLA2R)-positive membranous nephropathy (MN) is a primary glomerular disease.
Related Concept Videos
01:26Kidney Transplant II: Surgical Procedure
01:28Kidney Transplant I: Introduction