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Heterogeneous Presentations of iMCD: A Single-Institution Case Series
Jaspreet Kaur1, Anthony Sisk2, Jonathan E Zuckerman2
1Division of Hematology/Oncology, University of California San Francisco, Fresno 93701-2302, California, USA.
Case Reports in Hematology
|November 12, 2025
Summary
Idiopathic multicentric Castleman disease (iMCD) presents diagnostic challenges due to its varied symptoms. Early recognition and siltuximab treatment are crucial for managing this rare hematological disorder.
Area of Science:
- Hematology
- Oncology
- Rare Diseases
Background:
- Idiopathic multicentric Castleman disease (iMCD) is a rare lymphoproliferative disorder characterized by lymph node hyperplasia.
- iMCD presents with diverse symptoms, ranging from mild to life-threatening organ failure, complicating diagnosis.
- Heterogeneous histopathological features and clinical presentations pose diagnostic challenges for clinicians.
