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Related Experiment Videos

Interaction between delta(9)-tetrahydrocannabinol and d-amphetamine.

C Hattendorf, M Hattendorf, H Coper

    Psychopharmacology
    |October 20, 1977
    PubMed
    Summary

    Delta-9-tetrahydrocannabinol (THC) and d-amphetamine have additive effects on food and water intake. Despite tolerance to THC, d-amphetamine

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    Area of Science:

    • Neuroscience
    • Pharmacology
    • Psychopharmacology

    Background:

    • d-Amphetamine is a stimulant known to increase motor activity and affect neurotransmitter levels.
    • Delta-9-tetrahydrocannabinol (THC), the primary psychoactive component of cannabis, has complex interactions with amphetamine.
    • Understanding the combined effects of these substances is crucial for psychopharmacological research.

    Purpose of the Study:

    • To investigate the synergistic or antagonistic effects of d-amphetamine and THC on motor activity, body weight, and neurotransmitter concentrations in rats.
    • To examine the development of tolerance to THC and potential cross-tolerance with d-amphetamine.

    Main Methods:

    • Administration of varying doses of d-amphetamine and THC to rats.
    • Measurement of motor activity, food and water intake, and body weight.
    • Quantification of dopamine (DA) and norepinephrine (NE) concentrations in brain tissue.

    Main Results:

    • THC dose-dependently diminished d-amphetamine-induced motor activity but prolonged stereotype movements.
    • Both substances reduced food/water intake and body weight gain additively.
    • THC potentiated d-amphetamine-induced dopamine increases in the brain stem; no cross-tolerance was observed.

    Conclusions:

    • THC and d-amphetamine exhibit complex interactions, with THC antagonizing some amphetamine effects while potentiating others.
    • Subchronic THC treatment leads to tolerance but does not induce cross-tolerance to d-amphetamine's effects.
    • These findings highlight distinct neurochemical pathways modulated by THC and d-amphetamine.

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