Related Experiment Video
Updated: Jan 11, 2026

Introduction of Intracapsular Rotary-cut Procedures IRCP: A Modified Hysteromyomectomy Procedures Facilitating Fertility Preservation
Published on: January 17, 2019
Relationship between uterine fibroids and risk of cancers: Population-based retrospective cohort study
Hee-Yeong Jung1, Tae-Ran Kim1, Myoung-Hwan Kim2
1Apple Obstetrics and Gynecology Clinic, Seoul, Korea.
Objective:
Numerous studies have assessed the relationship between estrogen and cancer, and an association between uterine fibroids and an increased risk of endometrial cancer and thyroid cancer has been found. However, previous studies are limited by small sample sizes and lack of information on patient characteristics. This population-based retrospective cohort study aimed to confirm the association between uterine fibroids and cancer risk.
Methods:
This population-based retrospective cohort study used insurance information recorded in the Korea's Health Insurance Review and Assessment Service from January 1, 2009, to December 31, 2020. Patients with a diagnosis of uterine fibroids and uterine fibroid removal surgery code were included in the uterine fibroid group. Women who visited a clinic for a health checkup were included in the non-uterine fibroid group.
Results:
In total, 714 171 individuals were studied, 492 610 in the non-uterine fibroids group and 221 561 in the uterine fibroids group. The all-site cancer hazard ratio (HR) of the uterine fibroid group was higher than that of the non-uterine fibroid group (all sites: HR, 1.399, confidence interval [CI]: 1.346-1.454), with HR for breast 1.263 (CI: 1.177-1.354), uterus 2.459 (CI: 2.009-3.010), ovary 1.349 (CI: 1.097-1.659), kidney 1.432 (CI: 1.014-2.022), thyroid 1.693 (CI: 1.591-1.800), and retroperitoneum and peritoneum 3.059 (CI: 1.263-7.414).
Conclusion:
Surgically treated uterine fibroids are associated with increased cancer risk. They are associated with an increased risk of breast, uterine, ovarian, kidney, thyroid, peritoneal, and retroperitoneal cancers.
More Related Videos
06:46Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
13:04In Vivo and Ex Vivo Approaches to Study Ovarian Cancer Metastatic Colonization of Milky Spot Structures in Peritoneal Adipose
Published on: October 14, 2015
Related Concept Videos
Cancer Prevention
Some...
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Relative Risk
Longitudinal Research
Disorders of the Female Reproductive System