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Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines

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Mesothelioma in Situ With a TP53 Mutation.

Andrew Churg¹, Erika Haase², Raheela Siddiqui³

¹Department of Pathology, Vancouver General Hospital, and University of British Columbia, Vancouver, BC, Canada.

The American Journal of Surgical Pathology

|November 12, 2025

Summary

This study details a rare peritoneal mesothelioma case linked to a TP53 gene deletion. P53 overexpression suggests its potential role in diagnosing mesothelioma in situ.

Keywords:

BAP1 MTAP NF2 TP53 mesothelioma in situ

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Desthiobiotin-Streptavidin-Affinity Mediated Purification of RNA-Interacting Proteins in Mesothelioma Cells

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Published on: April 25, 2018

Area of Science:

Oncology
Genetics
Pathology

Background:

Mesothelioma in situ (MIA) is a precursor to invasive mesothelioma.
Most MIA cases feature BAP1 mutations.
The genetic landscape of MIA is not fully understood.

Purpose of the Study:

To report a unique case of MIA progressing to invasive mesothelioma.
To investigate the genetic alterations associated with this specific MIA case.
To explore the potential diagnostic utility of p53 in MIA.

Main Methods:

Case study of a 55-year-old male patient.
Immunohistochemistry for BAP1, MTAP, NF2/merlin, and p53.
Analysis of a long in-frame TP53 deletion.

Main Results:

The patient presented with peritoneal mesothelioma.
Immunohistochemistry revealed retained BAP1, MTAP, and NF2/merlin.
Overexpression of p53 was observed in MIA and invasive mesothelioma.
A long in-frame TP53 deletion was identified.

Conclusions:

This is the first reported case of MIA associated with a TP53 mutation.
TP53 alterations may play a role in MIA development and progression.
p53 immunohistochemistry may aid in the diagnosis of mesothelioma in situ.