Related Experiment Video

Updated: Jan 11, 2026

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines
08:01

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines

Published on: April 21, 2022

2.2K

Mesothelioma in Situ With a TP53 Mutation

Andrew Churg1, Erika Haase2, Raheela Siddiqui3

  • 1Department of Pathology, Vancouver General Hospital, and University of British Columbia, Vancouver, BC, Canada.

The American Journal of Surgical Pathology
|November 12, 2025
PubMed

Insights

This study details a rare peritoneal mesothelioma case linked to a TP53 gene deletion. P53 overexpression suggests its potential role in diagnosing mesothelioma in situ.

Area of Science:

  • Oncology
  • Genetics
  • Pathology

Background:

  • Mesothelioma in situ (MIA) is a precursor to invasive mesothelioma.
  • Most MIA cases feature BAP1 mutations.
  • The genetic landscape of MIA is not fully understood.

Purpose of the Study:

  • To report a unique case of MIA progressing to invasive mesothelioma.
  • To investigate the genetic alterations associated with this specific MIA case.
  • To explore the potential diagnostic utility of p53 in MIA.

Main Methods:

  • Case study of a 55-year-old male patient.
  • Immunohistochemistry for BAP1, MTAP, NF2/merlin, and p53.
  • Analysis of a long in-frame TP53 deletion.

Main Results:

  • The patient presented with peritoneal mesothelioma.
  • Immunohistochemistry revealed retained BAP1, MTAP, and NF2/merlin.
  • Overexpression of p53 was observed in MIA and invasive mesothelioma.
  • A long in-frame TP53 deletion was identified.

Conclusions:

  • This is the first reported case of MIA associated with a TP53 mutation.
  • TP53 alterations may play a role in MIA development and progression.
  • p53 immunohistochemistry may aid in the diagnosis of mesothelioma in situ.
Keywords:
BAP1MTAPNF2TP53mesothelioma in situ

More Related Videos

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice07:54

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

Published on: December 21, 2019

7.2K
Desthiobiotin-Streptavidin-Affinity Mediated Purification of RNA-Interacting Proteins in Mesothelioma Cells11:11

Desthiobiotin-Streptavidin-Affinity Mediated Purification of RNA-Interacting Proteins in Mesothelioma Cells

Published on: April 25, 2018

8.6K

Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.1K