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Updated: Jan 11, 2026
Combining Peripheral Nerve Grafting and Matrix Modulation to Repair the Injured Rat Spinal Cord
Published on: November 20, 2009
Peripheral nerve regeneration using a biodegradable conduit from açaí (Euterpe oleracea): a bio-based alternative to
Rui Sergio Monteiro de Barros1, Deivid Ramos Dos Santos2, Vitor Nagai Yamaki3
1Hospital Porto Dias - Departamento de Ortopedia e Traumatologia - Belém (PA) - Brazil.
Purpose:
To evaluate the regenerative efficacy of an experimental biodegradable nerve conduit composed of polycaprolactone and açaí-derived polyurethane, used for peripheral nerve repair, in comparison with different reconstructive techniques.
Methods:
Wistar rats (n = 48) were allocated into six groups (n = 8): normality (NG), denervated (DG), burial (BG), nerve autograft (NAG), açaí-based neurotube (ANG), and vein autograft (VAG). Sciatic functional index, electrophysiological parameters, and histomorphometry were assessed after 12 weeks.
Results:
NAG and ANG showed significant functional recovery, with ANG being the only group to demonstrate progressive improvement (p = 0.009). Electrophysiological analysis revealed higher amplitude and lower latency in NAG, followed by ANG and VAG. Histomorphometric analysis showed increased axonal density in ANG and NAG compared to non-reconstructed groups (p = 0.004 and p = 0.007, respectively).
Conclusion:
The polycaprolactone/açaí-based conduit demonstrated regenerative performance comparable to autologous nerve grafts.
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