Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Wheatstone Bridge01:29

Wheatstone Bridge

1.1K
An ohmmeter is a resistance-measuring device. It works by applying a voltage to a resistor of unknown resistance and measuring the current across the resistor. The resistance value is deduced using Ohm's law. Usually, the standard configuration of an ohmmeter comprises a voltmeter or an ammeter. However, such configurations are limited in accuracy because the meters alter the voltage applied to the resistor and the current that flows through it.
Thus, for accurate resistance measurements, a...
1.1K
Design Example: Strain Gauge Bridge or Wheatstone Bridge01:15

Design Example: Strain Gauge Bridge or Wheatstone Bridge

913
The utilization of strain gauges as transducers for converting mechanical strain into electrical signals is a common practice in various engineering applications. These strain gauges are frequently integrated into Wheatstone bridge circuits to accurately measure parameters such as force or pressure. Within this context, each element within the circuit exhibits a resistance that undergoes subtle variations when subjected to mechanical strain. The primary objective is to convert minuscule...
913
Survey Safety01:28

Survey Safety

345
Surveying near highways, rough terrain, or power lines involves significant risks. Working along highways is particularly dangerous and requires the use of warning signs and flagmen. It is safest to avoid working directly on roads and use offsets whenever possible. When highway work is unavoidable, it must follow all safety guidelines. Surveyors should wear bright clothing, such as orange reflective vests, to ensure visibility to motorists, coworkers, and hunters. In construction zones, wearing...
345
Bridge rectifier01:24

Bridge rectifier

1.4K
The bridge rectifier is essential in electronics for efficiently converting alternating current (AC) to direct current (DC). Comprised of four diodes configured in a bridge layout, this rectifier effectively processes both the positive and negative halves of the AC waveform, making it superior to half-wave and full-wave center-tapped rectifiers in terms of voltage regulation and output stability.
Operationally, the bridge rectifier allows current flow through two of its diodes during each...
1.4K
Schemas01:42

Schemas

12.3K
A schema is a mental construct consisting of a cluster or collection of related concepts (Bartlett, 1932). There are many different types of schemata, and they all have one thing in common: schemata are a method of organizing information that allows the brain to work more efficiently. When a schema is activated, the brain makes immediate assumptions about the person or object being observed.
12.3K
Anchoring Junctions01:03

Anchoring Junctions

4.7K
Anchoring junctions are multiprotein complexes that help cells connect to other cells and the extracellular matrix. Anchoring junctions are present on the lateral and basal surfaces of cells, providing strong and flexible connections. Focal adhesions are often formed due to cell interactions with the ECM substrata, which initiate signal transduction via kinase cascades and other mechanisms. Together, they provide stability and tissue integrity. There are three types of anchoring junctions:...
4.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

UMAD1 contributes to ESCRT-III dynamic subunit turnover during cytokinetic abscission.

Journal of cell science·2023
Same journal

The Rab GEF VINE couples phosphatase recruitment to GAP-mediated Rab5 inactivation.

The Journal of cell biology·2026
Same journal

Intercellular mitochondrial transfer and trans-mitophagy in response to protein import dysfunction.

The Journal of cell biology·2026
Same journal

aPKC exclusion from the apical cortex in enteroblasts maintains stem cell homeostasis in Drosophila.

The Journal of cell biology·2026
Same journal

A pan-vertebrate signaling motif controls the molecular function of intracellular AQP12.

The Journal of cell biology·2026
Same journal

Synergistic assembly, disassembly, and protection of complex forms of bundled F-actin.

The Journal of cell biology·2026
Same journal

Recruitment and release of XPG during NER is controlled by pre- and post-incision factors and EXO1.

The Journal of cell biology·2026
See all related articles

Related Experiment Video

Updated: Jan 6, 2026

Evaluation of an Exclusive Spur Dike U-Turn Design with Radar-Collected Data and Simulation
11:41

Evaluation of an Exclusive Spur Dike U-Turn Design with Radar-Collected Data and Simulation

Published on: February 1, 2020

20.8K

Sensing danger at the bridge.

Juan Martin-Serrano1

  • 1Department of Infectious Diseases, Faculty of Life Sciences & Medicine, King's College London, London, UK.

The Journal of Cell Biology
|November 12, 2025
PubMed
Summary
This summary is machine-generated.

Researchers identified Srs2 and PARI helicases as key sensors for NoCut, a mechanism that protects genome integrity. These helicases initiate signaling to delay cell division when DNA bridges occur.

More Related Videos

Sensing of Barrier Tissue Disruption with an Organic Electrochemical Transistor
11:17

Sensing of Barrier Tissue Disruption with an Organic Electrochemical Transistor

Published on: February 10, 2014

12.1K
A Strain Gauge Monitor SGM for Continuous Valve Gape Measurements in Bivalve Molluscs in Response to Laboratory Induced Diel-cycling Hypoxia and pH
07:59

A Strain Gauge Monitor SGM for Continuous Valve Gape Measurements in Bivalve Molluscs in Response to Laboratory Induced Diel-cycling Hypoxia and pH

Published on: August 1, 2018

9.3K

Related Experiment Videos

Last Updated: Jan 6, 2026

Evaluation of an Exclusive Spur Dike U-Turn Design with Radar-Collected Data and Simulation
11:41

Evaluation of an Exclusive Spur Dike U-Turn Design with Radar-Collected Data and Simulation

Published on: February 1, 2020

20.8K
Sensing of Barrier Tissue Disruption with an Organic Electrochemical Transistor
11:17

Sensing of Barrier Tissue Disruption with an Organic Electrochemical Transistor

Published on: February 10, 2014

12.1K
A Strain Gauge Monitor SGM for Continuous Valve Gape Measurements in Bivalve Molluscs in Response to Laboratory Induced Diel-cycling Hypoxia and pH
07:59

A Strain Gauge Monitor SGM for Continuous Valve Gape Measurements in Bivalve Molluscs in Response to Laboratory Induced Diel-cycling Hypoxia and pH

Published on: August 1, 2018

9.3K

Area of Science:

  • Cell Biology
  • Genetics
  • Molecular Biology

Background:

  • Persistent DNA bridges pose a threat to genome integrity.
  • The NoCut pathway prevents chromosome breakage during cell division.
  • The sensing mechanism for NoCut-mediated genome protection remains unclear.

Purpose of the Study:

  • To identify the molecular sensors involved in the NoCut pathway.
  • To understand how missegregation events, specifically DNA bridges, are detected.
  • To elucidate the signaling cascade initiated by NoCut sensors.

Main Methods:

  • Utilized genetic screening and molecular assays.
  • Investigated the roles of conserved helicases in DNA damage response.
  • Analyzed the effects of helicase activity on cell division timing.

Main Results:

  • Identified Srs2 and PARI helicases as crucial NoCut sensors.
  • Demonstrated that these helicases initiate signaling pathways.
  • Showed that this signaling delays cytokinetic abscission in the presence of DNA bridges.

Conclusions:

  • Srs2 and PARI helicases are conserved sensors of DNA bridges.
  • These helicases trigger a conserved signaling pathway to delay cell division.
  • This mechanism ensures genome integrity by preventing premature cytokinesis.