Sonic Serenity: Piezoelectric Nanomaterials Reshaping Wound Healing Paradigms

Chronic wounds caused by infections pose a significant healthcare challenge due to the rise of antibiotic-resistant bacteria. Ultrasound-driven sonodynamic therapy (SDT) has emerged as a promising alternative, leveraging reactive oxygen species (ROS) for bacterial eradication. The integration of piezoelectric nanomaterials (NMs) with SDT (PSDT) enhances antimicrobial efficacy and accelerates wound healing by inducing electric stimulation. Recent studies highlight the potential of piezoelectric hydrogels and nanocomposites in promoting tissue regeneration. However, challenges remain in optimizing piezoelectric responses, ensuring biosafety, and improving ROS generation for clinical applications. Further research is essential to advance PSDT for effective bacterial-resistant wound treatments.