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Postpandemic Recovery of Case Mix Index and Risk-Adjusted Mortality in US Hospitals
Chris DeRienzo1,2, David Levine3, Saloni Jain3
1American Hospital Association, Chicago, Illinois.
JAMA Network Open
|November 12, 2025
Summary
Hospital mortality rates declined post-COVID-19, returning to prepandemic improvement trends. However, patient acuity, measured by case mix index (CMI), remains higher than before the pandemic, suggesting a new baseline.
Area of Science:
- Healthcare quality research
- Epidemiology
- Health services research
Background:
- The COVID-19 pandemic significantly impacted hospital quality and patient safety metrics.
- There is a need to understand if established trends in hospital outcomes have resumed post-pandemic.
Purpose of the Study:
- To evaluate if risk-adjusted mortality and case mix index (CMI) trends among hospitalized patients have returned to their pre-pandemic trajectories.
- To analyze changes in hospital quality indicators following the COVID-19 pandemic.
Main Methods:
- Retrospective cohort study utilizing the Vizient Clinical Data Base (over 1300 US hospitals).
- Analysis of inpatient discharges from October 2019 to March 2024.
- Employed ordinary least squares (OLS) and joinpoint regression to assess trends and identify inflection points in CMI and standardized mortality ratio (SMR).
Main Results:
- Mean CMI increased from 1.70 (Q4 2019) to 1.79 (Q1 2024), with no significant overall linear trend but an inflection point in Q4 2020.
- Mean standardized mortality ratio (SMR) decreased from 1.00 (Q4 2019) to 0.80 (Q1 2024), showing a significant linear decline across the study period.
- An SMR inflection point was identified in Q3 2021, after which SMR declined significantly by -3.17% per quarter.
Conclusions:
- Risk-adjusted in-hospital mortality has significantly declined post-pandemic, resuming its prepandemic improvement trajectory.
- Patient acuity, as indicated by CMI, has remained elevated, suggesting a new postpandemic baseline.
- Hospital mortality outcomes have returned to prior improvement trends, despite increased patient acuity.
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