Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

2.0K
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.0K
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

420
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
420
Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

757
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
757
Dementia01:30

Dementia

503
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
503
Hypoglycemia and Glucagon01:15

Hypoglycemia and Glucagon

787
Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
787
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

1.6K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Associations between fall risk increasing drugs (FRID) and fall & fall injuries in older Black and White men and women: the Health, Aging and Body Composition Study.

Archives of gerontology and geriatrics·2026
Same author

Lifestyle and Metformin Interventions and Risk of Multimorbidity in Adults With Prediabetes.

JAMA·2026
Same author

Associations of obesity phenotypes with incident fall rates: results from the objective physical activity and cardiovascular disease health in older women study.

The journals of gerontology. Series A, Biological sciences and medical sciences·2026
Same author

Author response to OSIN-D-26-00532: self-paced stair climb and handrail use may mask links to injurious falls.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2026
Same author

A Bayesian network analysis of gait speed change upon transition to uneven surfaces in older adults.

The journals of gerontology. Series A, Biological sciences and medical sciences·2026
Same author

FRIENDS GUI: A Graphical User Interface for Data Collection and Visualization of Vaping Behavior from a Passive Vaping Monitor.

Journal of open research software·2026
Same journal

Understanding Person-Centeredness in a Systemic Perspective: Implications for Long-Term Care.

Journal of applied gerontology : the official journal of the Southern Gerontological Society·2026
Same journal

Adaptation Outcomes of a CAPABLE-Family Open-Label Pilot Study for Community-Dwelling Older Adults With Mild Cognitive Impairment/Early Dementia and Disability.

Journal of applied gerontology : the official journal of the Southern Gerontological Society·2026
Same journal

Marital Satisfaction and Frailty in Later Life: Asymmetric, Gendered, and Distributional Associations.

Journal of applied gerontology : the official journal of the Southern Gerontological Society·2026
Same journal

The Need to Reconstruct "Person-Centeredness" Based on Inherent Tensions.

Journal of applied gerontology : the official journal of the Southern Gerontological Society·2026
Same journal

Global Perspectives on Person-Centered Dementia Care: Results of an International Survey.

Journal of applied gerontology : the official journal of the Southern Gerontological Society·2026
Same journal

Physical, Cognitive and Social Characteristics of Frail Older Adults Associated With Their Discharge Destination Following Hospitalization.

Journal of applied gerontology : the official journal of the Southern Gerontological Society·2026
See all related articles

Related Experiment Video

Updated: Jan 11, 2026

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid
06:21

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid

Published on: April 7, 2023

2.0K

Cognitive Function, Diabetes, and Recurrent Falls: From the Health ABC Study.

Amy C Ellis1, Chuong Bui2, Andrea L Rosso3

  • 1Department of Human Nutrition, The University of Alabama, Tuscaloosa, AL, USA.

Journal of Applied Gerontology : the Official Journal of the Southern Gerontological Society
|November 12, 2025
PubMed
Summary
This summary is machine-generated.

Diabetes increases the risk of recurrent falls in older adults, but physical function may mediate this link. Maintaining cognitive function consistently lowers fall risk, independent of diabetes status.

Keywords:
cognitive functiondiabetesfallsphysical function

More Related Videos

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats
07:41

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats

Published on: October 23, 2020

6.7K
Author Spotlight: Innovations in iTUG Test for Enhanced Risk Assessment and Cognitive Insights
05:26

Author Spotlight: Innovations in iTUG Test for Enhanced Risk Assessment and Cognitive Insights

Published on: October 25, 2024

1.7K

Related Experiment Videos

Last Updated: Jan 11, 2026

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid
06:21

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid

Published on: April 7, 2023

2.0K
Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats
07:41

Behavioral Assessment of Visual Function via Optomotor Response and Cognitive Function via Y-Maze in Diabetic Rats

Published on: October 23, 2020

6.7K
Author Spotlight: Innovations in iTUG Test for Enhanced Risk Assessment and Cognitive Insights
05:26

Author Spotlight: Innovations in iTUG Test for Enhanced Risk Assessment and Cognitive Insights

Published on: October 25, 2024

1.7K

Area of Science:

  • Gerontology
  • Epidemiology
  • Neuroscience

Background:

  • Diabetes is a prevalent chronic condition in older adults.
  • Recurrent falls are a major cause of injury and disability in the elderly.
  • The interplay between diabetes, cognition, and falls requires further investigation.

Purpose of the Study:

  • To examine the associations between diabetes, cognitive performance, and recurrent falls in community-dwelling older adults.
  • To investigate the potential mediating role of physical function in the diabetes-fall relationship.
  • To determine if cognitive function influences fall risk independently of diabetes.

Main Methods:

  • Longitudinal analysis of the Health, Aging and Body Composition study cohort.
  • Inclusion of men and women aged 70-79, initially free of mobility limitations.
  • Assessment of diabetes status, recurrent falls, cognitive scores (Digit Symbol Substitution Test), and physical performance over 10 years.

Main Results:

  • Participants with diabetes exhibited higher odds of recurrent falls (OR = 1.38).
  • This association was not significant after controlling for physical function (OR = 1.23).
  • Higher cognitive scores were associated with lower odds of recurrent falls (OR = 0.96), irrespective of physical function or diabetes status.

Conclusions:

  • Physical function may mediate the relationship between diabetes and recurrent falls in older adults.
  • Cognitive function is a significant protective factor against falls, independent of diabetes.
  • Strategies to maintain physical and cognitive health are crucial for fall prevention in aging populations.