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Related Concept Videos

Telomeres and Telomerase02:41

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In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded...
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Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
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Updated: Jan 11, 2026

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circHERC1-A telomerase activator.

Yumeng Cui1, Yingying He1, Xiaojie Wu1

  • 1Laboratory of Advanced Biotechnology, Beijing Institute of Biotechnology, Beijing 100071, China.

Science Advances
|November 12, 2025
PubMed
Summary

Circular RNA HERC1 (circHERC1) reactivates telomerase reverse transcriptase (TERT) in aging cells. Restoring circHERC1 improves telomere length, reverses aging signs, and enhances function, offering a novel anti-aging therapeutic target.

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Area of Science:

  • Molecular Biology
  • Aging Research
  • Genomics

Background:

  • Telomere maintenance and genomic stability are critical, with telomerase activity typically decreasing in aged somatic cells.
  • Telomerase reverse transcriptase (TERT) is the catalytic subunit of telomerase, essential for telomere maintenance.

Purpose of the Study:

  • To investigate the role of circHERC1 in regulating telomerase activity and its potential as an anti-aging intervention.
  • To elucidate the mechanism by which circHERC1 influences TERT transcription.

Main Methods:

  • Identification of circHERC1 as a TERT transcription regulator.
  • Analysis of circHERC1 binding to the TERT promoter and recruitment of RNA polymerase II and c-Fos.
  • Assessment of circHERC1 expression changes with age.
  • Experimental restoration of circHERC1 levels in aged models.
  • In vivo delivery of circHERC1 via adeno-associated virus vectors and extracellular vesicles.

Main Results:

  • circHERC1 directly binds the TERT promoter, promoting TERT expression by recruiting key transcriptional machinery.
  • circHERC1 levels decline with age, correlating with reduced telomerase activity.
  • Restoring circHERC1 enhances telomerase activity, elongates telomeres, and reverses aging phenotypes.
  • circHERC1 delivery mitigates senescence, improves cognitive and physical function, and reduces inflammation in aged models.

Conclusions:

  • circHERC1 is a novel regulator of telomerase activity and a key factor in the aging process.
  • circHERC1 restoration represents a promising therapeutic strategy for combating age-related decline and promoting longevity.