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Oromucosal as an Alternative Method for Administration of Cannabis Products in Rodents
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Edible cannabis use on simulated driving performance.

Nae Y Won1, Sarah Bird2, Julia Wrobel3

  • 1Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

Traffic Injury Prevention
|November 12, 2025
PubMed
Summary
This summary is machine-generated.

Edible cannabis use impairs driving performance, with occasional users showing greater deficits than daily users. This suggests tolerance plays a role in driving impairment beyond THC levels alone.

Keywords:
Ediblescannabis impaired drivingcannabis usedriving performancedriving simulatordrug impaired driving

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Transportation Safety

Background:

  • Cannabis use, particularly edibles, is increasing, raising concerns about public safety.
  • Understanding the impact of cannabis on driving is crucial for policy and prevention.
  • THC (delta-9-tetrahydrocannabinol) is the primary psychoactive component in cannabis.

Purpose of the Study:

  • To evaluate the effects of edible cannabis consumption on driving performance.
  • To examine how frequency of cannabis use influences driving impairment.
  • To investigate the impact of different road settings (urban vs. rural) on driving after cannabis use.

Main Methods:

  • 88 adults (25-55 years) in Denver, CO, were grouped by recent cannabis use: daily, occasional, or none.
  • Driving performance (speed, lane departures, lateral placement) was assessed using a driving simulator (miniSim™).
  • Tests were conducted at baseline and two intervals (52 and 119 minutes) post-consumption, analyzed with linear mixed models.

Main Results:

  • Daily cannabis users drove slower than occasional and non-users, particularly in urban settings.
  • Occasional users exhibited increased lane departures and greater standard deviation of lateral placement (SDLP) in rural settings.
  • Impairment in occasional users was more pronounced compared to daily users, indicating a potential role of tolerance.

Conclusions:

  • Edible cannabis consumption leads to significant driving performance decrements.
  • Driving impairment duration and severity vary based on frequency of use and road environment.
  • Cannabis tolerance may mitigate driving impairment, suggesting factors beyond THC concentration influence driving outcomes.