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Related Concept Videos

Bone Disorders01:29

Bone Disorders

5.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Blood and Nerve Supply to the Bones01:29

Blood and Nerve Supply to the Bones

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Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
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Fractures: Bone Repair01:27

Fractures: Bone Repair

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Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
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Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

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The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
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Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

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Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
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Related Experiment Video

Updated: Jan 11, 2026

Author Spotlight: Developing a Rat Model for Weight-Bearing Intervention to Investigate Osteonecrosis of the Femoral Head
05:55

Author Spotlight: Developing a Rat Model for Weight-Bearing Intervention to Investigate Osteonecrosis of the Femoral Head

Published on: September 27, 2024

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Does Covid-19 Cause Avascular Necrosis?

Kübra Canarslan-Demir1, Kübra Ozgok-Kangal1, Esat Artan2

  • 1Department of Underwater and Hyperbaric Medicine, Gülhane Training and Research Hospital, University of Health Sciences, Ankara, Türkiye.

Undersea & Hyperbaric Medicine : Journal of the Undersea and Hyperbaric Medical Society, Inc
|November 12, 2025
PubMed
Summary
This summary is machine-generated.

COVID-19 infection is linked to a rise in avascular necrosis (AVN), a serious joint condition. This study found more AVN cases, particularly affecting the hip, after the pandemic, suggesting a connection that warrants further investigation.

Keywords:
COVID-19avascular necrosis of bonehyperbaric oxygenationlong COVIDpandemics

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Area of Science:

  • Orthopedics
  • Infectious Diseases
  • Rheumatology

Background:

  • Avascular Necrosis (AVN) is a debilitating condition affecting various joints.
  • The potential link between COVID-19 and increased AVN risk requires thorough investigation.
  • Understanding this association is crucial for timely diagnosis and effective management.

Purpose of the Study:

  • To evaluate the impact of COVID-19 on the incidence and characteristics of Avascular Necrosis.
  • To identify potential risk factors for AVN development post-COVID-19.
  • To enhance clinical awareness regarding COVID-19-associated AVN.

Main Methods:

  • Retrospective cohort study design.
  • Analysis of AVN patients treated with Hyperbaric Oxygen Therapy (HBOT) between January 2018 and January 2023.
  • Comparison of AVN cases diagnosed before (control) and after (study) the COVID-19 pandemic.

Main Results:

  • A significant increase in AVN cases was observed in the post-pandemic period.
  • Patients with a history of COVID-19 showed a higher incidence of femoral head AVN.
  • More advanced stages of AVN were noted in the post-pandemic cohort, especially those with COVID-19 history.

Conclusions:

  • COVID-19 infection may be an emerging risk factor for Avascular Necrosis.
  • High-dose corticosteroid use in conjunction with COVID-19 may further elevate AVN risk.
  • Clinical vigilance for joint pain and careful steroid management are recommended for patients with a history of COVID-19.