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Related Concept Videos

Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure01:16

Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure

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Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
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Hypoxia is a medical condition characterized by an inadequate oxygen supply to body tissues. It typically manifests as a bluish discoloration of the skin and mucosae, especially in fair-skinned individuals, when hemoglobin (Hb) saturation drops below 75%.
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IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
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Managing flail chest, a condition characterized by a segment of the chest wall moving independently from the rest of the thoracic cage, requires a comprehensive approach. It includes a thorough assessment of the patient's condition, a diagnostic evaluation to determine the extent of the injury, and the implementation of appropriate medical interventions tailored to the individual's needs.
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Hemoglobin (Hb) is a crucial molecule in the human body, consisting of four polypeptide chains, each bound to an iron-containing heme group. This unique structure enables hemoglobin to bind to oxygen, with each molecule capable of combining with four molecules of oxygen, leading to rapid and reversible oxygen loading. When fully loaded with oxygen, it is called oxyhemoglobin, while hemoglobin that has released oxygen is called reduced hemoglobin or deoxyhemoglobin. As hemoglobin binds oxygen,...
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Related Experiment Video

Updated: Jan 11, 2026

Oxygen-Glucose Deprivation and Reoxygenation as an In Vitro Ischemia-Reperfusion Injury Model for Studying Blood-Brain Barrier Dysfunction
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Acute Traumatic Ischemias: Roles of Hyperbaric Oxygen.

Michael B Strauss

    Undersea & Hyperbaric Medicine : Journal of the Undersea and Hyperbaric Medical Society, Inc
    |November 12, 2025
    PubMed
    Summary

    Acute traumatic ischemia, a costly condition, includes crush injuries and open fractures. Hyperbaric oxygen therapy shows potential for improving outcomes in these severe cases.

    Area of Science:

    • Trauma Surgery
    • Hyperbaric Medicine
    • Orthopedic Surgery

    Background:

    • Acute traumatic ischemias encompass a range of conditions like crush injuries, compartment syndromes, burns, frostbite, and compromised re-implantations.
    • These conditions pose a significant economic burden, with $672 billion spent on trauma care in 2016.
    • Severe cases, such as Gustilo Grade III-B & C open fractures, have high complication rates (50%) despite advanced care.

    Purpose of the Study:

    • To discuss surgical types of traumatic ischemias, with a focus on crush injuries.
    • To highlight the potential of hyperbaric oxygen (HBO₂) in mitigating the pathophysiology of traumatic ischemias.
    • To explore HBO₂'s role in improving outcomes for patients with predictably poor prognoses.

    Main Methods:

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  • Review of surgical classifications of traumatic ischemias.
  • Focus on crush injuries as a primary example.
  • Discussion of the underlying pathophysiology common to various traumatic ischemias.

    • Main Results:

    • Hyperbaric oxygen (HBO₂) possesses mechanisms that can counteract the pathophysiology of traumatic ischemias.
    • HBO₂ offers potential for improved outcomes in patients with severe traumatic ischemias.
    • The pathophysiology of various traumatic ischemias shares similarities, suggesting a unified therapeutic approach.

    Conclusions:

    • Hyperbaric oxygen therapy presents a promising adjunctive treatment for acute traumatic ischemias.
    • Understanding the shared pathophysiology is key to optimizing treatment strategies.
    • Further research into HBO₂ for traumatic ischemias, including crush injuries, is warranted.