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Updated: Jan 11, 2026

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From tetrazole to isoquinolinone: Structure-based optimization and late-stage diversification of AR-C118925-derived

Rayan Aboalgasim Makawi Abdalrahman1, Katja Schlegel2, Victor Hugo Catricala Fernandes3

  • 1University of Tuebingen, Department of Preclinical Imaging and Radiopharmacy, Cluster of Excellence iFIT (EXC 2180) "Image-guided and Functionally Instructed Tumor Therapies", Roentgenweg 13, 72076, Tuebingen, Germany.

European Journal of Medicinal Chemistry
|November 12, 2025
PubMed

Keywords:
AR-C118925AntagonistsBioisosteresLate-stage diversificationP2Y(2) receptorStructure-activity relationships

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