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Published on: December 15, 2023
Postpartum Hepatitis B Exacerbation Following Discontinuation of Nucleotide Analogue Therapy
Ryo Takada1,2, Soichiro Shimizu1, Yuichi Yamazaki2
1Department of Hepatology, Kiryu Kosei General Hospital, Japan.
Abstract:
A woman in her 20s from Vietnam, an asymptomatic hepatitis B virus (HBV) carrier with a high viral load, was initiated on tenofovir disoproxil fumarate (TDF) at 31 weeks of gestation. TDF was discontinued after delivery; however, at eight weeks postpartum, she developed an acute exacerbation of hepatitis, characterized by elevated ALT levels and HBV DNA rebound. Although the risk of hepatitis flares following TDF discontinuation is generally considered low, this case highlights the potential for severe postpartum exacerbation and underscores the importance of considering continued antiviral therapy in the postpartum period.
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