Related Experiment Video
Updated: Jan 11, 2026
Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
Spindle Cell Lesions
Yaileen D Guzmán-Arocho1, Laura C Collins2
1Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA, USA.
None:
Spindle cell lesions in the breast encompass a heterogeneous group of lesions, including reactive processes, and benign and malignant neoplasms. Management and prognosis vary substantially according to the diagnosis. However, differentiating between these lesions can be difficult, especially when only limited biopsy samples are available. In this article, we highlight the main spindle cell lesions encountered in the breast, including microscopic findings, immunohistochemistry profile, molecular findings, and pitfalls.
Related Concept Videos
02:19The Spindle Assembly Checkpoint
Many proteins function together to control the spindle assembly checkpoint. Mutations affecting these proteins may allow cells to proceed into anaphase prematurely, resulting in the...
02:27The Mitotic Spindle
The bipolar configuration of the mitotic spindle facilitates chromosomal segregation, preparing the cell for division. One mechanism that ensures...
01:51Lampbrush Chromosomes
LBCs are made up of two pairs of conjugating homologous chromatids. Each chromatid consists of alternatively positioned regions of condensed-inactive chromatin and loosely placed-active side loops, which can be contracted and extended. The loops...
02:50Spindle Assembly
In most cells, centrosomes are the primary microtubule nucleation centers. In the centrosome-mediated pathway, the G2-prophase transition triggers centrosome maturation and increased microtubule nucleation. Progressive nucleation results in a...