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Contemporary Approaches to Adrenocortical Carcinoma
Alexa J Hughes1, Alexandria D McDow2, Hadley E Ritter2
1Department of Surgery, Surgical Outcomes and Quality Improvement Center (SOQIC), Indiana University School of Medicine, 545 Barnhill Drive, Emerson Hall, Indianapolis, IN, USA.
Hematology/Oncology Clinics of North America
|November 12, 2025
Summary
Adrenocortical carcinoma, a rare cancer, is best treated with surgery for early stages. Advanced cases currently rely on mitotane chemotherapy, while new treatments are under investigation.
Area of Science:
- Oncology
- Endocrinology
Background:
- Adrenocortical carcinoma (ACC) is a rare and aggressive endocrine malignancy.
- It is associated with a poor prognosis, necessitating effective treatment strategies.
Purpose of the Study:
- To summarize current management approaches for adrenocortical carcinoma.
- To highlight the role of surgery, chemotherapy, and emerging therapies.
Main Methods:
- Review of current literature on adrenocortical carcinoma treatment.
- Analysis of standard and investigational therapeutic modalities.
Main Results:
- Surgical resection is the primary curative option for early-stage ACC.
- Mitotane-based chemotherapy is the standard for advanced disease.
- Ongoing trials explore immunotherapy and targeted therapies with preliminary results.
Conclusions:
- Management of ACC involves a multi-modal approach tailored to disease stage.
- Surgical intervention is crucial for localized disease.
- Further research is needed to integrate novel therapies into standard ACC treatment guidelines.
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