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Generative Artificial Intelligence for Exposure Therapy: Guidelines for Clinicians and Patients
Andrew M Sherrill1, Dominik O Mattioli2, Rebecca L Schneider3
1Emory University School of Medicine, Atlanta, GA, USA andrew.m.sherrill@emory.edu.
Journal of Cognitive Psychotherapy
|November 12, 2025
Summary
Generative artificial intelligence (GenAI) can enhance exposure therapy for anxiety and trauma disorders by personalizing exercises. GenAI serves as a supportive tool for clinicians, not a replacement for their expertise.
Area of Science:
- Psychiatry
- Artificial Intelligence
- Psychotherapy
Background:
- Exposure therapy is a cornerstone treatment for anxiety and trauma-related disorders.
- Generative artificial intelligence (GenAI) is rapidly evolving, offering new technological capabilities.
- Integrating novel tools into established therapeutic practices requires careful consideration.
Purpose of the Study:
- To provide practical guidance for clinicians and patients on utilizing GenAI in exposure therapy.
- To explore the ethical considerations and fundamental applications of GenAI within clinical settings.
- To outline how GenAI can be leveraged for creating personalized exposure stimuli and hierarchies.
Main Methods:
- Review of GenAI capabilities relevant to therapeutic applications.
- Discussion of ethical frameworks for AI in mental health.
- Practical examples of GenAI for generating exposure materials (images, videos, scripts, conversational agents).
- Guidance on using GenAI for exposure hierarchy development.
Main Results:
- GenAI can assist in creating diverse and personalized exposure stimuli.
- GenAI tools can aid in the structured development of exposure hierarchies.
- Ethical considerations and clinical integration strategies are crucial for effective use.
- GenAI can serve as an ancillary tool to augment, not replace, clinical judgment.
Conclusions:
- GenAI offers significant potential to enhance the personalization and efficacy of exposure therapy.
- Clinician training and clear organizational messaging are vital for successful GenAI adoption.
- The future of exposure therapy can be advanced through the responsible integration of GenAI.
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