Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

Ligand-Gated Ion Channel Receptor: Gating Mechanism

Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Deletion of neurosecretory proteins GL and GM drives dual anti-obesity effects via appetite suppression and enhanced energy expenditure.

Communications biology·2026
Same author

A highly sensitive genetically encoded red cAMP sensor for multiplex imaging in vivo.

Nature communications·2026
Same author

The adenosine A<sub>2A</sub> receptor antagonist KW6002 mitigates aldosterone-induced central serous chorioretinopathy in mice.

Neuropharmacology·2026
Same author

Discovery of Trolox amide derivatives as potent membrane-targeted ferroptosis inhibitors for corneal injury therapy.

European journal of medicinal chemistry·2026
Same author

The superior colliculus gates dopamine responses to conditioned stimuli in visual classical conditioning.

Nature communications·2026
Same author

ATP release from the amygdala-prefrontal pathway regulates vulnerability to social stress in male mice.

Molecular psychiatry·2026

Related Experiment Video

Updated: May 13, 2026

Intracranial Injection of Adeno-associated Viral Vectors
08:47

Intracranial Injection of Adeno-associated Viral Vectors

Published on: November 17, 2010

48.7K

Adenosine in the Brain: Recent Progress on Detection, Function, and Translation.

Takaki Yahiro1, Philip Hwang2, Francesca Logiacco3,4

  • 1Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|November 12, 2025
PubMed
Summary
This summary is machine-generated.

Adenosine is a key brain neuromodulator regulating sleep, movement, and cognition. Recent advances illuminate its function and therapeutic potential for neurological disorders.

More Related Videos

Imaging of Intracellular ATP in Organotypic Tissue Slices of the Mouse Brain using the FRET-based Sensor ATeam1.03YEMK
11:20

Imaging of Intracellular ATP in Organotypic Tissue Slices of the Mouse Brain using the FRET-based Sensor ATeam1.03YEMK

Published on: December 19, 2019

10.5K
Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
05:17

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451

Published on: April 18, 2025

781

Related Experiment Videos

Last Updated: May 13, 2026

Intracranial Injection of Adeno-associated Viral Vectors
08:47

Intracranial Injection of Adeno-associated Viral Vectors

Published on: November 17, 2010

48.7K
Imaging of Intracellular ATP in Organotypic Tissue Slices of the Mouse Brain using the FRET-based Sensor ATeam1.03YEMK
11:20

Imaging of Intracellular ATP in Organotypic Tissue Slices of the Mouse Brain using the FRET-based Sensor ATeam1.03YEMK

Published on: December 19, 2019

10.5K
Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
05:17

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451

Published on: April 18, 2025

781

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Pharmacology

Background:

  • Adenosine's role in the brain, identified decades ago, is now rapidly expanding.
  • Innovative technologies have accelerated our understanding of adenosine's function.
  • Adenosine is recognized as a crucial neuromodulator in the central nervous system.

Purpose of the Study:

  • To review recent advancements in understanding adenosine's role in brain function.
  • To highlight the molecular mechanisms of adenosine production and signaling.
  • To explore adenosine's potential as a therapeutic target for neurological and psychiatric conditions.

Main Methods:

  • Review of recent scientific literature.
  • Analysis of technological advances in adenosine detection.
  • Examination of in vitro and in vivo studies on adenosine signaling.

Main Results:

  • Adenosine dynamically regulates brain circuits involved in sleep/wakefulness, movement, cognition, and homeostasis.
  • Molecular mechanisms of adenosine production and downstream signaling are key therapeutic targets.
  • Progress has been made in detecting adenosine and unraveling its signaling pathways.

Conclusions:

  • Adenosine is a vital neuromodulator with significant implications for brain function.
  • Understanding adenosine pathways offers promise for treating neuropsychiatric and neurodegenerative diseases.
  • Continued research is essential to fully elucidate adenosine's complex roles in the brain.