Spaceflight Standard Measures is a multidisciplinary study that systematically monitors risks to astronaut health and...

Spaceflight Standard Measures is an integrated research study designed to characterize how spaceflight affects the health and performance of astronauts. Standardizing the research methods allows for robust monitoring of individuals and allows comparison between crewmembers of different missions of various durations. This manuscript reviews the objectives of the Spaceflight Standard Measures project, and details how each disciplinary component is used to monitor spaceflight-induced human risks. It also covers the timeline of data collection, the methods used to analyze the data, and the process for requesting access to the data. With the impending return to lunar operations and exploration of deep space, an urgent need exists for high-quality, multidisciplinary investigations to inform programmatic and operational decisions. The Spaceflight Standard Measures model provides a standardized, flexible research approach, fostering collaboration across agencies to create a strong evidence base that can be used to safely advance human spaceflight into multiplanetary exploration.