Effects of Changes in Metabolic Syndrome Status on Cognitive Function: A 10-Year Study in a Middle-Aged Population
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View abstract on PubMed
Summary
This summary is machine-generated.Persistent metabolic syndrome (MS) over 10 years is linked to cognitive decline, especially in women. Early intervention in midlife may reduce future cognitive deterioration risks.
Area Of Science
- Neuroscience
- Endocrinology
- Public Health
Background
- Metabolic syndrome (MS) is a cluster of conditions increasing cardiovascular risk.
- The long-term impact of metabolic syndrome on cognitive function is not fully understood.
- Sex differences in metabolic syndrome and cognitive decline warrant investigation.
Purpose Of The Study
- To examine the longitudinal relationship between metabolic syndrome status changes and cognitive performance over 10 years.
- To determine if sex modifies the association between metabolic syndrome and cognitive decline.
- To identify specific cognitive domains affected by persistent metabolic syndrome.
Main Methods
- Longitudinal study of 766 participants (mean baseline age 54 years) from the Kaohsiung Atherosclerosis Longitudinal Study.
- Metabolic syndrome defined using modified NCEP ATP III criteria for Asian populations.
- Participants categorized into: never MS, ever MS, new MS, persistent MS. Cognition assessed via Montreal Cognitive Assessment (MoCA).
- Multivariate regression analyses adjusted for covariates including age, sex, education, lifestyle factors, and mental health.
Main Results
- Persistent metabolic syndrome was associated with lower MoCA scores compared to never MS (β = -0.08, p = 0.020), particularly in memory and language domains.
- This association was significant in women (β = -0.12, p = 0.004) but not in men (β = -0.03, p = 0.628).
- No significant cognitive decline was observed in individuals with non-persistent MS (ever or new MS).
Conclusions
- Persistent metabolic syndrome over a decade is a risk factor for cognitive decline, especially in women.
- Early and sustained management of metabolic syndrome in midlife is crucial for preserving cognitive function in later life.
- Findings underscore the importance of sex-specific considerations in metabolic syndrome management to mitigate cognitive risks.
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