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Eight Triplex-Binding Molecules from Four Chemical Classes Broadly Recognize the MALAT1 Triple Helix

Madeline M Mousseau1, Krishna M Shivakumar1, Jaesang Yoo1

  • 1Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, USA.

Molecules (Basel, Switzerland)
|November 13, 2025
PubMed
Summary

Small molecules called triplex-binding molecules (TBMs) can interact with the MALAT1 triple helix. These TBMs show potential for targeting cancer cells by reducing MALAT1 levels.

Keywords:
MALAT1MENβsmall moleculetriple helix

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