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Related Experiment Video

Updated: Jan 11, 2026

Author Spotlight: Advancements in Nanoparticle Technology for Drug Delivery and Immunotherapy

Author Spotlight: Advancements in Nanoparticle Technology for Drug Delivery and Immunotherapy

Published on: November 10, 2023

Nano-Based Vaccine Delivery Systems: Innovative Therapeutics Against Cancer and Neurological Disorders.

Sarfraz Ahmed¹, David Gozal², Abdelnaby Khalyfa¹

¹Department of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA.

International Journal of Molecular Sciences

|November 13, 2025

Summary

This summary is machine-generated.

Nanoparticles enhance vaccine immunogenicity and stability for complex diseases like cancer and neurological disorders. This review explores nanoparticle delivery systems and adjuvants for improved therapeutic outcomes.

Keywords:

cancer immunotherapeutics liposomes nano-based vaccines nanocarriers nanoparticles neurological disorders vaccine delivery systems

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Delivery of Therapeutic siRNA to the CNS Using Cationic and Anionic Liposomes

Delivery of Therapeutic siRNA to the CNS Using Cationic and Anionic Liposomes

Published on: July 23, 2016

Area of Science:

Biomedical science
Immunology
Nanotechnology

Background:

Vaccines are crucial for disease eradication but often fail to elicit comprehensive immune responses.
Nanoparticles (NPs) offer a novel delivery approach to enhance vaccine immunogenicity and stability.
Existing NP-based vaccines show potential but struggle with complex diseases like cancer and neurological disorders.

Purpose of the Study:

To review recent advancements in nanoparticle-based vaccines and delivery systems.
To highlight NP innovations for cancer and neurological disorder immunotherapeutics.
To discuss the role of adjuvants and NP properties in modulating immune responses.

Main Methods:

Review of current literature on nanoparticle-based vaccines and delivery systems.
Analysis of NP characteristics (composition, charge, size) influencing immune responses.
Exploration of adjuvant strategies, including Toll-like receptor (TLR) agonists.

Main Results:

NP-based formulations significantly enhance vaccine immunogenicity and stability.
NP properties modulate biodistribution, antigen targeting, and antigen-presenting cell (APC) trafficking.
Lipid-based NPs, especially mRNA-encapsulating ones, show adaptability for diverse vaccine applications.

Conclusions:

Nanotechnology presents a viable solution for developing vaccines against complex diseases.
NP-based systems offer promising avenues for cancer and neurological disorder immunotherapies.
Further research into NP characteristics and adjuvant combinations is crucial for optimizing vaccine efficacy.