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Microorganisms in Medicine and Therapeutics01:29

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Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
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Related Experiment Video

Updated: Jan 11, 2026

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Bio-Active Peptides from Marine Sources: Mechanistic Insights into Immune Regulation, Microbiota Modulation, and

Farman Ali1, Dailin Li1, Yunpeng Su1

  • 1College of Basic Medical Sciences, Dalian Medical University, Dalian 116044, China.

International Journal of Molecular Sciences
|November 13, 2025
PubMed
Summary

Marine peptides from octopus, conch, and scallop show promise for gut health. These natural compounds modulate the immune system, reduce inflammation, and improve gut microbiota balance, aiding conditions like inflammatory bowel disease.

Keywords:
IBDgut microbiotaimmune modulationintestinal barriermarine peptidesnatural products

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Area of Science:

  • Marine biotechnology
  • Immunology
  • Gastroenterology

Background:

  • Marine bioactive compounds, particularly peptides, are gaining attention for their health benefits.
  • These peptides possess immunomodulatory, antioxidant, and gut microbiota-regulating properties.
  • They offer potential therapeutic strategies for inflammatory bowel disease (IBD) and related gastrointestinal disorders.

Purpose of the Study:

  • To review current research on marine-derived peptides from octopus, sea conch, and scallop.
  • To highlight their therapeutic potential in restoring intestinal integrity and immune function.
  • To explore their mechanisms of action and applications in gut health and beyond.

Main Methods:

  • Review of existing literature on marine peptides.
  • Analysis of in vivo studies, including dextran sodium sulfate (DSS)-induced colitis and cyclophosphamide-induced immunosuppression models.
  • Examination of molecular mechanisms involving tight junction proteins, inflammatory pathways, and gut microbiota composition.

Main Results:

  • Marine peptides effectively restore intestinal integrity by increasing tight junction proteins (ZO-1, occludin) and mucin production.
  • They modulate immune responses by reducing pro-inflammatory cytokines and inhibiting pathways like NF-κB and TLR-4.
  • These peptides promote beneficial gut bacteria, such as Lactobacillus and Lachnospiraceae, rebalancing dysbiotic microbiota.

Conclusions:

  • Marine-derived peptides from specific shellfish demonstrate significant therapeutic potential for gastrointestinal health.
  • Their ability to interact with the gut-immune-microbiota axis makes them valuable for managing IBD and immune dysfunction.
  • Further research into clinical translation and drug development is warranted for these versatile marine bioactives.