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Urinary Tract Infection in a Small Animal Model: Transurethral Catheterization of Male and Female Mice
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The Urinary Microbiota and the Gut-Bladder Axis in Bladder Cancer
Usman Akhtar Butt1, Daniela De Biase1
1Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Corso della Repubblica 79, 04100 Latina, Italy.
International Journal of Molecular Sciences
|November 13, 2025
Summary
The human bladder
Area of Science:
- Microbiology
- Urology
- Oncology
Background:
- The human bladder harbors a low-biomass microbial community known as the urobiota.
- The urobiota's role in bladder health and its contrast to other mucosal microbiota are not fully understood.
- Urobiota alterations are linked to urogenital conditions like urinary tract infections (UTIs).
Purpose of the Study:
- To review recent research on the urobiota's association with bladder cancer (BC).
- To explore the potential of urobiota as biomarkers for BC diagnosis and therapeutic monitoring.
- To discuss novel methodologies and the gut-bladder axis in BC research.
Main Methods:
- Analysis of urobiota in urine specimens from bladder cancer patients.
- Application of novel culturing techniques like culturomics.
- Utilizing animal models and 3D organotypic models of bladder cancer.
- Review of studies investigating the gut-bladder axis.
Main Results:
- Identification of potential microbial biomarkers and signatures associated with bladder cancer.
- Monitoring of therapeutic responses through urobiota analysis.
- Emerging evidence suggests the gut-bladder axis influences BC progression and treatment outcomes.
Conclusions:
- The urobiota represents an emerging area of study in bladder cancer.
- Urobiota analysis holds promise for BC biomarker discovery and treatment monitoring.
- The gut-bladder axis warrants further investigation for its role in bladder cancer.
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