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Protein Design Meets Single-Molecule Detection: Towards Programmable Nanopore Sensors
Xintong Liu1,2,3, Chunfu Xu1,3
1Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing 102206, China.
International Journal of Molecular Sciences
|November 13, 2025
Summary
Customizable nanopore sensors are advancing single-molecule detection for genomics and diagnostics. Computational design enables tailored nanopores for new biotechnological applications.
Area of Science:
- Biotechnology and Nanotechnology
- Molecular Diagnostics
- Genomics
Background:
- Natural nanopores are foundational for single-molecule detection.
- Limited diversity of natural pores necessitates engineered solutions.
- Protein engineering and de novo design enhance nanopore capabilities.
Purpose of the Study:
- To highlight advances in creating customizable nanopore sensors.
- To discuss the role of computational approaches in nanopore design.
- To explore the expanding applications of programmable nanopore technology.
Main Methods:
- Protein engineering for nanopore modification.
- De novo design of novel nanopore structures.
- Computational modeling for tailored nanopore geometries and functions.
Main Results:
- Development of customizable nanopore sensors with enhanced stability.
- Achieved specific molecular recognition functions through design.
- Demonstrated potential for real-time analysis in diverse applications.
Conclusions:
- Nanopore technology is evolving towards programmable sensors.
- Computational design is key to creating tailored nanopore sensors.
- These advancements promise broad applications in diagnostics and molecular biotechnology.
