Long-Term Complications of Multisystem Inflammatory Syndrome in Children and Adults Post-COVID-19: A Systematic Review
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View abstract on PubMed
Summary
This summary is machine-generated.Multisystem inflammatory syndrome (MIS) post-COVID-19 affects multiple organs, primarily the heart. Early recognition and multidisciplinary care are crucial for managing this severe post-viral complication in children and adults.
Area Of Science
- Infectious Diseases
- Immunology
- Cardiology
Background
- The SARS-CoV-2 pandemic presents significant global health challenges, impacting multiple organ systems.
- Multisystem inflammatory syndrome, affecting both children (MIS-C) and adults (MIS-A), is a severe post-COVID-19 complication.
Purpose Of The Study
- To compile and analyze published data on clinical characteristics, laboratory findings, and outcomes of MIS post-COVID-19.
- To investigate MIS-related complications in pediatric and adult populations following COVID-19 infection.
Main Methods
- A comprehensive literature search was conducted across multiple databases.
- Data from 64 selected studies were extracted and analyzed by independent reviewers.
Main Results
- Cardiac complications were the most frequent manifestation, followed by gastrointestinal, hematologic, neurological, and mucocutaneous involvement.
- Elevated inflammatory markers (CRP, ferritin, D-dimer, IL-6) were consistently observed.
- Most patients required hospitalization and intensive care, with treatments including IVIG, corticosteroids, and biologics.
Conclusions
- Early recognition, multidisciplinary management, and structured follow-up are essential for MIS patients.
- While most patients recover, some experience persistent complications.
- Further research is needed to elucidate underlying mechanisms, risk factors, and long-term outcomes.
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