A Scoping Review of CERAMENT™ Applications in Orthopedic Surgery

Area of Science:

• Orthopedic Surgery
• Biomaterials Science
• Regenerative Medicine

Background:

• Bone defects from trauma, infection, or tumors present significant orthopedic challenges.
• Autologous bone grafting has limitations including donor site morbidity and graft availability.
• CERAMENT™, a synthetic bone substitute (calcium sulfate/hydroxyapatite), offers osteoconductive, resorbable, and injectable properties.

Purpose of the Study:

• To conduct a scoping review of clinical applications of CERAMENT™ in orthopedic surgery.
• To evaluate the efficacy and outcomes of CERAMENT™ in various orthopedic procedures.
• To assess CERAMENT™ as an alternative to traditional bone grafting methods.

Main Methods:

• Scoping review following PRISMA-ScR guidelines.
• Literature search across PubMed, Embase, and Scopus databases.
• Study selection based on PICO framework for human orthopedic applications of CERAMENT™.

Main Results:

• 22 studies met inclusion criteria, evaluating CERAMENT™ in diverse orthopedic settings.
• CERAMENT™ demonstrated non-inferiority to autologous grafting in tibial plateau fractures (CERTiFy trial).
• Positive outcomes reported in chronic osteomyelitis, tumor defect reconstruction, spinal augmentation, and foot/ankle surgery, with reduced morbidity and faster recovery.

Conclusions:

• CERAMENT™ is a versatile and effective bone substitute for various orthopedic applications.
• Its clinical performance, ease of use, and antimicrobial properties support its routine use in orthopedics.
• Further research can refine indications and long-term benefits of CERAMENT™.