Alcoholic Liver Disease and Systemic Inflammatory Response Syndrome: Mortality Prediction Using Biomarkers and...

Area of Science:

• Hepatology
• Critical Care Medicine
• Clinical Biochemistry

Background:

• Cirrhosis, an irreversible liver disease, carries a high risk of mortality.
• Systemic Inflammatory Response Syndrome (SIRS) is a severe complication in cirrhotic patients, significantly increasing mortality.
• Understanding predictors of in-hospital mortality in this population is crucial for timely intervention.

Purpose of the Study:

• To assess the relationship between laboratory biomarkers, clinical scores, and in-hospital mortality in cirrhotic patients with SIRS.
• To identify reliable predictors for short-term (7-day) and medium-term (28-day) mortality.
• To evaluate the predictive value of the Cirrhosis Acute Gastrointestinal Bleeding (CAGIB) score.

Main Methods:

• A cohort of 102 patients with alcoholic cirrhosis and SIRS was studied.
• Laboratory values (sodium, chlorides, albumin), MELD, MELD-Na, APACHE II, CLIF-C OF, SII, and CAGIB scores were analyzed.
• Receiver operating characteristic (ROC) curves were used to assess mortality risk prediction.

Main Results:

• Sodium, chlorides, and albumin levels significantly correlated with 7-day and 28-day mortality.
• The Cirrhosis Acute Gastrointestinal Bleeding (CAGIB) score showed significant correlation with both 7-day and 28-day mortality.
• Specific cut-off values for the CAGIB score demonstrated predictive capabilities for mortality.

Conclusions:

• Sodium, chlorides, albumin, and the CAGIB score are identified as reliable predictors of in-hospital mortality.
• These markers are valuable for risk stratification in patients with advanced alcoholic liver disease and SIRS.
• The findings support the use of these indicators for predicting outcomes in critical cirrhotic patients.