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In Vivo Confocal Microscopy in the Diagnosis and Management of Dry Eye: A Focus on Imaging Protocols and Interpretation
Published on: November 11, 2025
444
Enhancing Safety in Refractive Surgery: A Pilot Evaluation of In Vivo Confocal Microscopy
Dominika Janiszewska-Bil1,2,3, Magdalena Kijonka4, Joanna Kokot-Lesiuk4
1Department of Ophthalmology, St. Barbara Hospital, Trauma Centre, 41-200 Sosnowiec, Poland.
Journal of Clinical Medicine
|November 13, 2025
Summary
In vivo confocal microscopy (IVCM) enhances refractive surgery assessment by detecting subclinical corneal abnormalities. This pilot study shows IVCM
Area of Science:
- Ophthalmology
- Corneal Imaging
- Refractive Surgery
Background:
- In vivo confocal microscopy (IVCM) offers high-resolution corneal imaging.
- It may improve preoperative and postoperative assessment in refractive surgery.
Purpose of the Study:
- Evaluate IVCM's diagnostic utility in detecting subclinical corneal abnormalities.
- Assess IVCM's impact on surgical qualification and outcomes.
Main Methods:
- Prospective pilot study of 7 patients undergoing refractive surgery evaluation.
- Comprehensive ophthalmic evaluation including IVCM, topography, and AS-OCT.
- Exclusion criteria included prior ocular surgery, infection, or systemic corneal disease.
Main Results:
- IVCM identified subtle epithelial, stromal, and endothelial abnormalities missed by conventional methods.
- Detected conditions like Thygeson's keratitis and subclinical herpes simplex keratitis.
- Led to modified surgical plans or disqualification in some cases.
Conclusions:
- IVCM is valuable for detecting subclinical corneal pathology in refractive surgery.
- It aids in patient selection and enhances surgical safety.
- Larger studies are needed to confirm its clinical role and establish screening guidelines.
