Is the EMpressin Injection in ENDOmetrioma eXcision Surgery Useful? The EMENDOX Study.

Area of Science:

• Gynecology
• Surgical Innovation
• Endometriosis Management

Background:

• Endometrioma recurrence post-laparoscopic cystectomy is a persistent clinical challenge.
• The Empressin Injection Technique (EIT) may enhance complete cyst removal, potentially reducing recurrence.
• This study evaluates EIT's impact on endometrioma recurrence rates versus standard cystectomy.

Purpose of the Study:

• To compare endometrioma recurrence rates between patients undergoing laparoscopic cystectomy with EIT and those with standard cystectomy.
• To assess the safety and efficacy of the Empressin Injection Technique in endometriosis surgery.
• To identify factors influencing recurrence in endometriosis patients.

Main Methods:

• Retrospective case-control study of 263 patients with endometriomas (2014-2024).
• Two groups: EIT (n=110) with vasopressin analog injection and control (n=153) without.
• Analysis included descriptive statistics and logistic regression to evaluate recurrence factors.

Main Results:

• No significant demographic or staging differences between EIT and control groups.
• Recurrence rates were significantly lower in the EIT group (5.5%) vs. control (19.6%) (p=0.001).
• No intraoperative/postoperative complications; comparable pregnancy rates; repeat surgery only in the control group.

Conclusions:

• Empressin Injection Technique significantly reduces endometrioma recurrence after laparoscopic cystectomy.
• EIT is safe and effective, especially when combined with postoperative hormonal therapy.
• This technique offers a promising advancement in managing endometriosis and preventing recurrence.