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Meldonium Improves Functional Capacity in Patients with Right Ventricular Failure.

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Summary

Meldonium improved exercise capacity and quality of life in patients with right ventricular failure (RVF). This study suggests meldonium may be a safe and effective treatment for RVF, a condition with no current therapies.

Keywords:
6MWTSF-36right ventricular failure

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Area of Science:

  • Cardiology
  • Pharmacology
  • Pulmonary Hypertension

Background:

  • Right ventricular failure (RVF) carries a poor prognosis and lacks specific treatments.
  • Meldonium, a cardiometabolic drug, demonstrated efficacy in preclinical RVF models.
  • Pulmonary arterial hypertension (PAH) is a common cause of RVF.

Purpose of the Study:

  • To evaluate the safety and efficacy of meldonium in patients suffering from PAH-induced RVF.
  • To assess meldonium's impact on exercise capacity and quality of life in RVF patients.

Main Methods:

  • A 30-day open-label trial involving 20 RVF patients treated with meldonium (500 mg, b.i.d.).
  • Assessment of exercise capacity using the 6-minute walk test (6MWT), WHO functional class (FC), Borg dyspnea score (BDS), and quality of life via the SF-36 questionnaire.
  • Monitoring of vital signs, blood biochemistry, and N-terminal pro-B-type natriuretic peptide (BNP) levels.

Main Results:

  • Meldonium significantly increased 6MWT distance (p=0.021) and improved WHO FC and SF-36 scores (p<0.05).
  • The Borg dyspnea score post-6MWT was significantly reduced (p=0.003) with meldonium treatment.
  • No adverse effects on vital signs or blood biochemistry, including BNP, were observed, indicating meldonium's safety in RVF patients.

Conclusions:

  • Meldonium treatment enhances functional capacity and improves the overall well-being of RVF patients.
  • The findings suggest meldonium as a potential novel therapeutic agent for RVF, addressing a critical unmet medical need.