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Lychee Fermented by Mixed Probiotic Strains Alleviates D-Galactose-Induced Skeletal Muscle and Intestinal Aging in
Huixian Han1, Jin Tao1, Xiaoyue Bai2
1Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100193, China.
Foods (Basel, Switzerland)
|November 13, 2025
Summary
Lychee fermentate (LF) combats aging effects in mice by improving muscle function and gut health. It reduces inflammation, oxidative stress, and restores gut microbiota balance, offering potential as a functional food for aging.
Area of Science:
- Gerontology
- Nutritional Science
- Microbiology
Background:
- Aging is linked to skeletal muscle and intestinal dysfunction.
- Chronic inflammation, oxidative stress, and gut dysbiosis are key drivers of aging.
- Developing interventions to mitigate age-related decline is crucial.
Purpose of the Study:
- To investigate the protective effects of lychee fermentate (LF) against D-galactose-induced aging in mice.
- To evaluate LF's impact on skeletal muscle and intestinal health.
- To explore the underlying mechanisms of LF's anti-aging properties.
Main Methods:
- Lychee fermentate (LF) prepared using mixed microbial fermentation.
- D-galactose-induced aging mouse model.
- Assessment of muscle function, colonic transit, senescence markers, gut histology, inflammation, oxidative stress, microbiota composition, and metabolomics.
Main Results:
- LF improved muscle strength, endurance, and fiber morphology.
- LF alleviated colonic transit issues, reduced senescence markers (p16, p21), and improved gut barrier function (MUC2, ZO-1, Claudin-1, Occludin).
- LF decreased inflammation (IL-1β, IL-6, TNF-α), oxidative stress (MDA, GPx, SOD), and modulated gut microbiota (Firmicutes/Bacteroidetes ratio, beneficial bacteria).
Conclusions:
- Lychee fermentate demonstrates significant anti-aging effects on skeletal muscle and the intestine.
- LF mitigates aging by reducing inflammation, oxidative stress, and restoring gut homeostasis.
- LF, enriched with phenolic acids and flavonoids, shows promise as a functional food for combating aging.
Keywords:
flavonoidgut microbiotaintestinal aginglychee fermentationmixed probioticsphenolic acidskeletal muscle agingMore Related Videos
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