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Modeling of Singlet Oxygen Generation and Thermal Effects During Laser-Tissue Interaction
1Department of Computational Mechanics and Engineering, Silesian University of Technology, Konarskiego 18A, 44-100 Gliwice, Poland.
Materials (Basel, Switzerland)
|November 13, 2025
Summary
This study models photodynamic therapy (PDT) phenomena, including laser energy deposition, heat transfer, and chemical reactions. The findings offer insights into optimizing PDT treatments for better outcomes.
Area of Science:
- Biomedical Engineering
- Photodynamic Therapy Research
Background:
- Photodynamic therapy (PDT) involves light, a photosensitizer, and oxygen to treat diseases.
- Accurate modeling of PDT phenomena is crucial for treatment optimization.
Purpose of the Study:
- To present a comprehensive analysis of phenomena occurring during photodynamic therapy (PDT).
- To develop and utilize models for laser energy deposition, bioheat transfer, and PDT reactions.
Main Methods:
- Optical diffusion equation for light distribution.
- Pennes' formula for bioheat transfer analysis.
- PDT reaction kinetics involving oxygen and photosensitizer concentrations.
- Boundary element, finite difference, and shooting methods for numerical calculations.
Main Results:
- Modeled tissue perfusion and scattering coefficients as thermally damage-dependent.
- Incorporated changes in capillary blood velocity affecting oxygen supply.
- Proposed a model for abnormal tumor vascular patterns and determined initial oxygen distribution.
Conclusions:
- The integrated modeling approach provides a detailed understanding of PDT processes.
- The models can be used to predict and optimize PDT treatment parameters.
- Consideration of dynamic tissue properties enhances PDT simulation accuracy.
