Modeling of Singlet Oxygen Generation and Thermal Effects During Laser-Tissue Interaction

This paper presents an analysis of the phenomena that occur during photodynamic therapy (PDT). For this purpose, models of laser energy deposition, bioheat transfer, and reactions occurring during the PDT process were used. Light distribution was estimated on the base of optical diffusion equation, while for the bioheat analysis the Pennes formula has been used. The PDT reaction model includes equations related to the concentration of triplet oxygen, photosensitizer, and singlet oxygen. The tissue perfusion coefficient and the effective scattering coefficient have been assumed to be thermally damage dependent. Changes in blood velocity in capillary, which affects maximum oxygen supply in PDT model, were also considered. A way of modeling the abnormal vascular pattern in the tumor area was also proposed, and the initial distribution of triplet oxygen in the tumor region was determined on the Krogh cylinder model. At the stage of numerical calculation, the boundary element method, the finite difference method, and the shooting method were used.