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The Establishment of a Murine Mandibular Molar Extraction Socket Healing Model
Published on: January 13, 2023
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Effect of Poly (Lactic Acid/ε-Caprolactone) Bilayer Membrane on Tooth Extraction Socket Wound Healing in a Rat Model
Bin Ji1, Tingyu Xie1,2, Ikiru Atsuta3
1Section of Implant and Rehabilitative Dentistry, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka 8128582, Japan.
Materials (Basel, Switzerland)
|November 13, 2025
Summary
A new synthetic bilayer membrane (PBM) shows promise for guided bone regeneration. It effectively separates bone and soft tissues, unlike current resorbable membranes, aiding bone healing without removal surgery.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Oral Surgery
Background:
- Guided bone regeneration (GBR) membranes are crucial for bone formation.
- Current resorbable membranes like poly (lactic-co-glycolic acid) (PLGA) have limitations, including animal-derived components and degradation control issues.
- A novel synthetic bilayer membrane (PBM) was developed with enhanced degradability and elasticity.
Purpose of the Study:
- To compare the wound-healing effects of the novel PBM and PLGA membranes in vivo and in vitro.
- To evaluate the potential of PBM as a space maintainer in GBR.
Main Methods:
- In vivo: Rat molar extraction sockets were covered with PBM or PLGA membranes, with histological evaluation at multiple time points.
- In vitro: Oral epithelial cells and fibroblasts were cultured on PBM to assess adhesion and protein permeability.
- Comparison of PBM and PLGA membranes for cell adhesion, protein permeability, and tissue integration.
Main Results:
- Both PBM and PLGA membranes showed similar mucosal healing in vivo.
- PBM effectively maintained a distinct bone-soft tissue boundary in extraction sockets.
- PBM demonstrated superior oral epithelial cell adhesion on one surface and better protein permeability compared to PLGA.
- Fibroblast adhesion was similar on both sides of PBM.
Conclusions:
- The synthetic PBM membrane effectively maintains space and separates bone from soft tissue in GBR applications.
- PBM exhibits favorable biocompatibility, including enhanced epithelial cell adhesion and protein permeability.
- PBM presents a promising alternative to existing resorbable membranes for guided bone regeneration.
