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Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer
Published on: September 8, 2023
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Evolving Resection Strategies for Non-Small Cell Lung Cancers: Translating Trial Evidence to Real-World Practice
Akshay J Patel1,2, Savvas Lampridis3,4, Andrea Bille5,6
1Division of Thoracic Surgery and Lung Transplantation, Toronto General Hospital, 200 Elizabeth Street, Toronto, ON M5G 2C4, Canada.
Cancers
|November 13, 2025
Summary
Sublobar resection is a new standard for early-stage non-small cell lung cancer (NSCLC), offering survival benefits over lobectomy. Rigorous nodal staging and patient selection are crucial for oncological validity in real-world practice.
Area of Science:
- Thoracic surgery
- Surgical oncology
- Pulmonary medicine
Background:
- Lobectomy is the traditional standard for early-stage non-small cell lung cancer (NSCLC).
- Recent trials (JCOG0802, CALGB140503) present conflicting evidence regarding sublobar resection versus lobectomy.
- Sublobar resection includes wedge resection and segmentectomy.
