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CircATP2C1 Drives Prostate Cancer Progression Through miR-654-3p-Mediated SLC7A11 Upregulation and Ferroptosis

Zhihai Deng1, Qiang Shen2, Nan Deng2

  • 1Department of Urology, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China.

Cancers
|November 13, 2025
PubMed
Summary

Circular RNA circATP2C1 promotes prostate cancer progression by inhibiting ferroptosis, a cell death process. Targeting circATP2C1 offers a new therapeutic strategy for advanced prostate cancer.

Keywords:
CircATP2C1SLC7A11ferroptosismiR-654-3pprostate cancer

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Prostate cancer is a common male genitourinary malignancy with poor survival rates in advanced stages.
  • Circular RNAs (circRNAs) and ferroptosis are implicated in prostate cancer progression, but their interaction is not well understood.

Purpose of the Study:

  • To investigate the role of circRNAs in regulating ferroptosis in prostate cancer.
  • To identify novel therapeutic targets for prostate cancer treatment.

Main Methods:

  • Bioinformatics analysis and human prostate cancer tissue microarrays were used to explore circRNA expression profiles.
  • Lentivirus was used to construct stable circRNA-knockdown or overexpressed prostate cancer cell lines.
  • AGO2-RNA immunoprecipitation (AGO2-RIP) identified circRNA-microRNA (miRNA) interactions.

Main Results:

  • circATP2C1 was found to be highly expressed in prostate cancer tissues.
  • circATP2C1 promoted prostate cancer cell proliferation, migration, and invasion by suppressing ferroptosis in vitro.
  • circATP2C1 enhanced prostate cancer tumorigenicity in vivo by inhibiting ferroptosis.

Conclusions:

  • circATP2C1 inhibits ferroptosis by increasing solute carrier family 7 member 11 (SLC7A11) expression via sponging miR-654-3p.
  • circATP2C1 plays an oncogenic role in prostate cancer.
  • circATP2C1 represents a potential therapeutic target for prostate cancer.