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Generative Artificial Intelligence-Driven Clinical Case Simulation in Temporomandibular Disorder Education: ChatGPT
Paula Rodrigues-Pereira1, Maria Amália Pereira Dias-Calças1, Alex Moreira Mélo1
1Departamento de Odontologia Restauradora, Faculdade de Odontologia de Ribeirão Preto, Universidade de São Paulo (FORP/USP), Ribeirão Preto, São Paulo, Brazil.
Journal of Dental Education
|November 13, 2025
Summary
Generative artificial intelligence (GAI) matched real patient simulations for diagnosing temporomandibular disorders (TMDs) and orofacial pain (OFP). GAI offers scalable, standardized training, complementing real-world clinical experiences for dental students.
Area of Science:
- Dental Education
- Artificial Intelligence in Medicine
- Diagnostic Reasoning
Background:
- Temporomandibular disorders (TMDs) and orofacial pain (OFP) require advanced diagnostic skills in dental education.
- Traditional patient simulations have limitations in availability and standardization.
- Generative artificial intelligence (GAI) presents a novel tool for clinical training.
Purpose of the Study:
- To compare the effectiveness of GAI (ChatGPT-3.5) versus standardized real patient simulations for training dental students in TMD/OFP diagnosis.
- To evaluate quantitative and qualitative aspects of student interactions with both simulation types.
Main Methods:
- A blinded, cross-sectional, crossover study involving 30 undergraduate dental students.
- Students completed two simulated cases: one with ChatGPT-3.5 and one with standardized real patients.
- Cases were validated by specialists; AI incorporated via structured prompts. Analysis included response metrics, information density, clarity, empathy, and diagnostic accuracy.
Main Results:
- GAI simulations demonstrated higher information density and clearer reasoning flow.
- Students required more follow-up questions and reformulations with real patients, indicating more adaptive communication.
- Diagnostic accuracy was comparable between GAI and real patient simulations; relevant information positively correlated with accuracy.
Conclusions:
- ChatGPT-3.5 provides comparable diagnostic reasoning to real patient simulations for TMD/OFP.
- Integrating GAI's scalability and standardization with real patient variability can enhance clinical competency training for dental professionals.
Keywords:
ChatGPT‐3.5artificial intelligenceclinical simulationdental educationorofacial paintemporomandibular disorders
