Safety and Tolerability of the 1440- and 1927-nm Non-Ablative Fractional Diode Laser System for Skin Resurfacing: A Review of Current Literature
Related Experiment Video
Updated: Jan 11, 2026
Author Spotlight: Advancing Facial Rejuvenation Therapy with Post-Laser Salicylic Acid Application
Published on: September 27, 2024
Roy G Geronemus1, Jordan V Wang2, Abby A Jacobson3
1New York University Medical Center, New York, New York, USA.
Background:
Energy-based devices, such as lasers, provide effective treatments for skin resurfacing. Ablative fractional lasers have a higher risk of adverse events (AEs), like scarring and postinflammatory hyperpigmentation, particularly in patients with darker skin types, than non-ablative fractional lasers. The 1440- and 1927-nm non-ablative fractional diode laser (NFDL) system is indicated for use in dermatological procedures requiring the coagulation of soft tissue and for general skin resurfacing procedures.
Aim:
To help inform clinical decision-making about the dual 1440/1927-nm NFDL system, particularly for treating patients with diverse skin types who require safe and effective resurfacing treatments.
Methods:
A PubMed search of literature was conducted to review safety and tolerability outcomes from clinical studies of 1440- and 1927-nm NFDL treatments.
Results:
Expected skin reactions, including erythema, edema, and crusting, were mild to moderate and self-limited for concurrent and individual use of the 1440- and 1927-nm handpieces. Mild discomfort and heat sensation, which were also expected, indicated that treatment was well tolerated. Safety was also demonstrated in patients with skin of color, with no serious AEs. Levels of patient satisfaction were high.
Conclusions:
The dual 1440/1927-nm NFDL system is a safe and well-tolerated option for resurfacing of diverse skin types with minimal postprocedural downtime and reduced risk of AEs relative to ablative lasers.
