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Tracking Dual-Pathway Self-Assembly via Butterfly-Motion-Based Molecular Fragment Conformational Transformation in

Yifan Wu1, Ruizi Shen1, Qiaochun Wang1

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Chemistry (Weinheim an Der Bergstrasse, Germany)
|November 13, 2025
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Summary
This summary is machine-generated.

Researchers developed chiral luminescent nanomaterials using peptides. They achieved controllable self-assembly into nanotoroids or nanorods with distinct circularly polarized luminescence (CPL) properties.

Keywords:
CPLhomopolypeptidemonitoringpeptidespolychromatic fluorescentself‐assembly

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Area of Science:

  • Supramolecular Chemistry
  • Materials Science
  • Biotechnology

Background:

  • Peptide-based luminescent nanomaterials are challenging due to weak fluorescence and complex self-assembly.
  • Chirality is inherent in peptides, offering potential for chiral optical properties.

Purpose of the Study:

  • To develop a straightforward strategy for directing supramolecular assembly of peptides.
  • To create efficient aqueous chiral luminescent nanomaterials with tunable properties.
  • To elucidate the relationship between morphology and chiroptical output.

Main Methods:

  • End-functionalizing homopolypeptides with a vibration-induced emission (VIE) motif.
  • Utilizing dual-pathway self-assembly monitored by ratiometric fluorescence.
  • Controlling morphology (nanotoroids vs. nanorods) via solvent selection.

Main Results:

  • Achieved real-time monitoring of self-assembly through fluorescence changes.
  • Demonstrated solvent-dependent formation of nanotoroids and nanorods.
  • Observed strong CPL activity in nanotoroids and CPL-silent nanorods.

Conclusions:

  • Established a versatile platform for constructing efficient aqueous CPL-active nanomaterials.
  • Elucidated the correlation between supramolecular morphology and chiroptical output.
  • Paved the way for rational design of biocompatible chiral luminescent systems.