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Related Experiment Video

Updated: Jan 11, 2026

Author Spotlight: Minimally Invasive Relief for Occipital Neuralgia at the Nuchal Line
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Author Spotlight: Minimally Invasive Relief for Occipital Neuralgia at the Nuchal Line

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Minimally Invasive, Micro-Autologous Fat Transfer for Secondary Occipital Neuralgia.

Giorgio Pietramaggiori1,2, Federico Ricci2, Alessandro Bastin2

  • 1Division of Aesthetic and Migraine Surgery, Global Medical Institute, Lausanne, Switzerland.

Pain Practice : the Official Journal of World Institute of Pain
|November 13, 2025
PubMed
Summary

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Autologous Fat Transfer (AFT) significantly reduced pain and medication use in patients with secondary occipital neuralgia. This regenerative treatment offers a promising, minimally invasive option for post-traumatic headaches.

Area of Science:

  • Regenerative Medicine
  • Neurology
  • Pain Management

Background:

  • Secondary occipital neuralgia (SON) is neuropathic pain following traumatic injury.
  • Current treatments include medications and local infiltrations.
  • Autologous fat transfer (AFT) may release scar tissue compressing nerves.

Purpose of the Study:

  • To evaluate Autologous Fat Transfer (AFT) for secondary occipital neuralgia (SON).
  • To assess AFT's efficacy in drug-resistant, post-traumatic headaches.

Main Methods:

  • Retrospective study of 19 patients with SON and occipital scarring.
  • Pain assessed via Visual Analog Scale (VAS), pain events, and medication intake.
  • Sensory testing included tactile detection thresholds and allodynia.
Keywords:
autologous fat transfermicro‐autologous fat transferoccipital neuralgiapost traumatic adherencesscar tissuesecondary neuralgia

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Main Results:

  • 18 of 19 patients showed >50% symptom reduction 12 months post-AFT.
  • Pain levels decreased from 8.7 to 3 on VAS.
  • Significant reductions in acute pain events (85%) and medication intake (74%) were observed.

Conclusions:

  • AFT is a novel, regenerative treatment for secondary occipital neuralgia.
  • This minimally invasive technique shows potential in managing post-traumatic headaches.
  • Further research is needed to elucidate AFT's mechanisms of action.