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Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

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Variation in Thyroid Function Tests in Acute Scrub Typhus Infection.

Sai N Gogineni¹, Adlyne R Asirvatham¹, Vasireddy N Tara¹

¹Department of Endocrinology and Metabolism, SRMC, Porur, Chennai, Tamil Nadu, India.

Indian Journal of Endocrinology and Metabolism

|November 13, 2025

Summary

This summary is machine-generated.

Thyroid function test (TFT) immunoassays can be affected by interference, particularly during acute scrub typhus infections. Confirming abnormal TFT results on a different platform is crucial to prevent misdiagnosis.

Keywords:

Assay interference free thyroid hormones scrub typhus

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Area of Science:

Clinical Chemistry
Infectious Diseases
Endocrinology

Background:

Immunoassays for thyroid function tests (TFTs) are susceptible to interference, potentially impacting clinical decisions.
The prevalence of assay interferences, even at 1%, can significantly increase the occurrence of abnormal TFT results.

Purpose of the Study:

To report cases of thyroid hormone assay interference in patients with acute scrub typhus infection.
To highlight the importance of considering assay interference when TFT results discord with clinical findings.

Main Methods:

A prospective observational study of patients with acute scrub typhus infection.
Thyroid function tests were initially performed using electrochemiluminescence immunoassay (ECLIA) and verified with Chemiluminescent Microparticle Immuno Assay (CMIA).

Main Results:

Initial ECLIA TFT showed elevated FT4 and FT3 with normal or low-normal TSH in six patients.
Re-analysis using CMIA within 24 hours revealed normal TFT results, suggesting assay interference.
TFT results normalized 6 weeks after recovery in all patients.

Conclusions:

Assay interference should be considered when clinical suspicion conflicts with biochemical TFT values.
Confirming abnormal TFT results on an alternative platform is essential to avoid misdiagnosis and inappropriate treatment.